Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Abdominal_aortic_aneurysm)
rsID Risk allele Effect size
rs6511720 T 0.215
rs10985349 T 0.158
rs9316871 G 0.140
rs2836411 T 0.107
rs6516091 A 0.123
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Abdominal_aortic_aneurysm)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 168 0.029 0.020 0.002 0.026 0.032
SOUTH 83 0.029 0.020 0.002 0.025 0.033
EAST 146 0.025 0.017 0.001 0.022 0.028
Populations
IBS 107 0.027 0.017 0.002 0.024 0.031
PIR 397 0.027 0.019 0.001 0.026 0.029
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Abdominal_aortic_aneurysm)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 107 397 0.9380 ns 1.000 ns
IBS WEST 107 168 0.4770 ns 1.000 ns
IBS SOUTH 107 83 0.5530 ns 1.000 ns
IBS EAST 107 146 0.3170 ns 1.000 ns
WEST SOUTH 168 83 0.9930 ns 1.000 ns
WEST EAST 168 146 0.0572 ns 0.572 ns
SOUTH EAST 83 146 0.1190 ns 1.000 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Abdominal_aortic_aneurysm)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 1.420 0.156 . white 1.540 0.124 . white 1.420 0.156 . white −0.030 0.976 . white
pct75.95 1.070 0.285 . white 0.150 0.881 . white 1.070 0.285 . white −0.280 0.779 . white
pct50.75 −2.940 0.003 ** −0.890 0.373 . white −2.940 0.003 ** −1.180 0.238 . white
pct25.50 1.280 0.201 . white −0.380 0.704 . white 1.280 0.201 . white 0.390 0.697 . white
pct25 −0.230 0.818 . white 0.350 0.726 . white −0.230 0.818 . white 1.030 0.303 . white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference