Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Acute_lymphoblastic_leukemia_childhood)
rsID Risk allele Effect size
rs17837497 A 0.850
rs1496766 C 1.044
rs9958208 A 0.482
rs546784 T 0.336
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Acute_lymphoblastic_leukemia_childhood)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 168 0.059 0.041 0.003 0.053 0.065
SOUTH 83 0.054 0.040 0.004 0.045 0.063
EAST 146 0.055 0.044 0.004 0.048 0.063
Populations
IBS 107 0.057 0.040 0.004 0.049 0.064
PIR 397 0.057 0.042 0.002 0.052 0.061
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Acute_lymphoblastic_leukemia_childhood)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 107 397 0.999 ns 1 ns
IBS WEST 107 168 0.640 ns 1 ns
IBS SOUTH 107 83 0.654 ns 1 ns
IBS EAST 107 146 0.816 ns 1 ns
WEST SOUTH 168 83 0.357 ns 1 ns
WEST EAST 168 146 0.439 ns 1 ns
SOUTH EAST 83 146 0.793 ns 1 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Acute_lymphoblastic_leukemia_childhood)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 0.180 0.857 . white 1.130 0.258 . white 0.180 0.857 . white 1.020 0.308 . white
pct75.95 0.270 0.787 . white 0.280 0.779 . white 0.270 0.787 . white −0.180 0.857 . white
pct50.75 −1.060 0.289 . white −0.840 0.401 . white −1.060 0.289 . white −0.440 0.660 . white
pct25.50 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white
pct25 0.700 0.484 . white 0.200 0.841 . white 0.700 0.484 . white 0.220 0.826 . white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference