Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Age-related_macular_degeneration)
rsID	Risk allele	Effect size
rs429608	G	0.554
rs4420638	A	0.262
rs1864163	G	0.199
rs13081855	T	0.207
rs8135665	T	0.140
rs334353	T	0.122
rs6795735	T	0.095
rs9542236	C	0.095
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Age-related_macular_degeneration)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.126	0.027	0.002	0.121	0.130
SOUTH	83	0.126	0.028	0.003	0.120	0.132
EAST	146	0.126	0.026	0.002	0.122	0.131
Populations
IBS	107	0.135	0.024	0.002	0.130	0.140
PIR	397	0.126	0.027	0.001	0.123	0.129

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Age-related_macular_degeneration)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.00174	**	0.0174	*
IBS	WEST	107	168	0.00378	**	0.0378	*
IBS	SOUTH	107	83	0.02070	*	0.2070	ns
IBS	EAST	107	146	0.01100	*	0.1100	ns
WEST	SOUTH	168	83	0.88000	ns	1.0000	ns
WEST	EAST	168	146	0.75900	ns	1.0000	ns
SOUTH	EAST	83	146	0.91700	ns	1.0000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Age-related_macular_degeneration)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.930	0.352	.	white	−2.770	0.006	**		−0.930	0.352	.	white	−3.050	0.002	**
pct75.95	−0.380	0.704	.	white	0.860	0.390	.	white	−0.380	0.704	.	white	0.550	0.582	.	white
pct50.75	−1.350	0.177	.	white	−2.160	0.031	*		−1.350	0.177	.	white	−0.760	0.447	.	white
pct25.50	0.200	0.841	.	white	−0.160	0.873	.	white	0.200	0.841	.	white	−0.100	0.920	.	white
pct25	2.340	0.019	*		3.090	0.002	**		2.340	0.019	*		2.200	0.028	*
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference