Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Allergic_sensitization)
rsID Risk allele Effect size
rs1059513 T 0.262
rs10056340 G 0.182
rs17616434 T 0.207
rs9865818 G 0.113
rs17454584 G 0.140
rs6932730 T 0.131
rs16887812 T 0.095
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Allergic_sensitization)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 168 0.088 0.018 0.001 0.086 0.091
SOUTH 83 0.090 0.019 0.002 0.086 0.094
EAST 146 0.088 0.019 0.002 0.085 0.091
Populations
IBS 107 0.088 0.021 0.002 0.084 0.092
PIR 397 0.088 0.018 0.001 0.087 0.090
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Allergic_sensitization)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 107 397 0.745 ns 1 ns
IBS WEST 107 168 0.832 ns 1 ns
IBS SOUTH 107 83 0.354 ns 1 ns
IBS EAST 107 146 0.932 ns 1 ns
WEST SOUTH 168 83 0.415 ns 1 ns
WEST EAST 168 146 0.743 ns 1 ns
SOUTH EAST 83 146 0.287 ns 1 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Allergic_sensitization)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 −0.390 0.697 . white −0.710 0.478 . white −0.390 0.697 . white −1.750 0.080 . white
pct75.95 0.350 0.726 . white −0.630 0.529 . white 0.350 0.726 . white 0.310 0.757 . white
pct50.75 0.420 0.674 . white 0.780 0.435 . white 0.420 0.674 . white 1.310 0.190 . white
pct25.50 0.960 0.337 . white 0.850 0.395 . white 0.960 0.337 . white 0.390 0.697 . white
pct25 −1.410 0.159 . white −0.620 0.535 . white −1.410 0.159 . white −1.090 0.276 . white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference