Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Alzheimer-s_disease)
rsID	Risk allele	Effect size
rs4663105	C	0.174
rs1582763	G	0.139
rs382216	C	0.139
rs476428	G	0.151
rs10498633	G	0.139
rs16847609	A	0.174
rs71380849	A	0.385
rs59616746	C	0.261
rs16830122	A	0.157
rs6110969	T	0.182
rs13146780	C	0.207
rs7920721	G	0.113
rs7207400	T	0.128
rs199499	C	0.151
rs61310603	T	0.174
rs2271920	A	0.104
rs75045569	T	0.139
rs78538083	C	0.278
rs71636213	G	0.166
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Alzheimer-s_disease)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.073	0.009	0.001	0.071	0.074
SOUTH	83	0.071	0.011	0.001	0.069	0.074
EAST	146	0.072	0.010	0.001	0.070	0.074
Populations
IBS	107	0.072	0.010	0.001	0.071	0.074
PIR	397	0.072	0.010	0.001	0.071	0.073

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Alzheimer-s_disease)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.804	ns	1	ns
IBS	WEST	107	168	0.850	ns	1	ns
IBS	SOUTH	107	83	0.470	ns	1	ns
IBS	EAST	107	146	0.751	ns	1	ns
WEST	SOUTH	168	83	0.336	ns	1	ns
WEST	EAST	168	146	0.572	ns	1	ns
SOUTH	EAST	83	146	0.635	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Alzheimer-s_disease)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.750	0.453	.	white	−1.180	0.238	.	white	−0.750	0.453	.	white	−0.890	0.373	.	white
pct75.95	1.240	0.215	.	white	0.820	0.412	.	white	1.240	0.215	.	white	0.340	0.734	.	white
pct50.75	−1.740	0.082	.	white	−0.840	0.401	.	white	−1.740	0.082	.	white	−0.400	0.689	.	white
pct25.50	0.030	0.976	.	white	1.310	0.190	.	white	0.030	0.976	.	white	0.710	0.478	.	white
pct25	0.930	0.352	.	white	−0.610	0.542	.	white	0.930	0.352	.	white	−0.100	0.920	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference