Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Alzheimer-s_disease_late_onset)
rsID	Risk allele	Effect size
rs6733839	T	0.199
rs983392	A	0.105
rs11218343	T	0.261
rs28834970	C	0.095
rs11771145	G	0.105
rs10948363	G	0.095
rs2718058	A	0.073
rs10498633	G	0.094
rs17125944	C	0.131
rs10838725	C	0.077
rs7274581	T	0.128
rs35349669	T	0.077
rs7818382	T	0.068
rs7295246	G	0.068
rs7920721	G	0.068
rs8035452	T	0.073
rs74615166	C	0.255
rs7225151	A	0.095
rs9381040	C	0.073
rs72807343	T	0.300
rs3865444	C	0.058
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Alzheimer-s_disease_late_onset)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.050	0.007	0.001	0.049	0.051
SOUTH	83	0.051	0.007	0.001	0.050	0.053
EAST	146	0.051	0.006	0.000	0.050	0.052
Populations
IBS	107	0.050	0.006	0.001	0.049	0.051
PIR	397	0.051	0.007	0.000	0.050	0.051

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Alzheimer-s_disease_late_onset)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.1470	ns	1.000	ns
IBS	WEST	107	168	0.4300	ns	1.000	ns
IBS	SOUTH	107	83	0.0757	ns	0.757	ns
IBS	EAST	107	146	0.1820	ns	1.000	ns
WEST	SOUTH	168	83	0.2260	ns	1.000	ns
WEST	EAST	168	146	0.5230	ns	1.000	ns
SOUTH	EAST	83	146	0.5130	ns	1.000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Alzheimer-s_disease_late_onset)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	1.100	0.271	.	white	1.200	0.230	.	white	1.100	0.271	.	white	1.030	0.303	.	white
pct75.95	1.790	0.073	.	white	1.560	0.119	.	white	1.790	0.073	.	white	0.460	0.646	.	white
pct50.75	−0.090	0.928	.	white	−1.950	0.051	.		−0.090	0.928	.	white	0.760	0.447	.	white
pct25.50	−1.810	0.070	.	white	−0.230	0.818	.	white	−1.810	0.070	.	white	−0.480	0.631	.	white
pct25	−0.280	0.779	.	white	0.050	0.960	.	white	−0.280	0.779	.	white	−1.220	0.222	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference