Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Amyotrophic_lateral_sclerosis)
rsID Risk allele Effect size
rs8056742 C 0.239
rs1971791 G 0.231
rs9533799 A 0.157
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Amyotrophic_lateral_sclerosis)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 168 0.069 0.041 0.003 0.063 0.076
SOUTH 83 0.065 0.038 0.004 0.057 0.073
EAST 146 0.070 0.034 0.003 0.064 0.075
Populations
IBS 107 0.068 0.042 0.004 0.060 0.076
PIR 397 0.069 0.038 0.002 0.065 0.072
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Amyotrophic_lateral_sclerosis)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 107 397 0.973 ns 1 ns
IBS WEST 107 168 0.856 ns 1 ns
IBS SOUTH 107 83 0.552 ns 1 ns
IBS EAST 107 146 0.792 ns 1 ns
WEST SOUTH 168 83 0.414 ns 1 ns
WEST EAST 168 146 0.922 ns 1 ns
SOUTH EAST 83 146 0.380 ns 1 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Amyotrophic_lateral_sclerosis)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 −1.350 0.177 . white −1.000 0.317 . white −1.350 0.177 . white −2.350 0.019 *
pct75.95 −0.210 0.834 . white 0.280 0.779 . white −0.210 0.834 . white 0.140 0.889 . white
pct50.75 −0.270 0.787 . white 0.080 0.936 . white −0.270 0.787 . white 1.650 0.099 . white
pct25.50 1.240 0.215 . white 1.600 0.110 . white 1.240 0.215 . white 1.500 0.134 . white
pct25 0.030 0.976 . white −1.150 0.250 . white 0.030 0.976 . white −1.960 0.050 *
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference