Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Asthma)
rsID	Risk allele	Effect size
rs404860	T	0.191
rs10508372	G	0.148
rs3129943	A	0.157
rs7775228	T	0.157
rs1701704	G	0.174
rs7686660	T	0.148
rs9275698	A	0.166
rs9500927	A	0.122
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Asthma)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.099	0.015	0.001	0.097	0.102
SOUTH	83	0.101	0.020	0.002	0.097	0.106
EAST	146	0.101	0.017	0.001	0.098	0.104
Populations
IBS	107	0.104	0.016	0.002	0.101	0.107
PIR	397	0.101	0.017	0.001	0.099	0.102

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Asthma)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.0836	ns	0.836	ns
IBS	WEST	107	168	0.0436	*	0.436	ns
IBS	SOUTH	107	83	0.3420	ns	1.000	ns
IBS	EAST	107	146	0.2500	ns	1.000	ns
WEST	SOUTH	168	83	0.4090	ns	1.000	ns
WEST	EAST	168	146	0.3610	ns	1.000	ns
SOUTH	EAST	83	146	0.9580	ns	1.000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Asthma)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.640	0.522	.	white	−2.120	0.034	*		−0.640	0.522	.	white	−1.160	0.246	.	white
pct75.95	1.670	0.095	.	white	−0.240	0.810	.	white	1.670	0.095	.	white	0.440	0.660	.	white
pct50.75	−1.820	0.069	.	white	0.610	0.542	.	white	−1.820	0.069	.	white	0.140	0.889	.	white
pct25.50	−0.560	0.575	.	white	−0.950	0.342	.	white	−0.560	0.575	.	white	−0.640	0.522	.	white
pct25	0.960	0.337	.	white	1.380	0.168	.	white	0.960	0.337	.	white	0.640	0.522	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference