Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Basal_cell_carcinoma)
rsID Risk allele Effect size
rs1805007 TRUE 0.438
rs12210050 TRUE 0.215
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Basal_cell_carcinoma)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 168 0.015 0.031 0.002 0.011 0.020
SOUTH 83 0.014 0.031 0.003 0.008 0.021
EAST 146 0.013 0.029 0.002 0.008 0.018
Populations
IBS 107 0.018 0.038 0.004 0.011 0.025
PIR 397 0.014 0.030 0.002 0.011 0.017
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Basal_cell_carcinoma)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 107 397 0.246 ns 1 ns
IBS WEST 107 168 0.472 ns 1 ns
IBS SOUTH 107 83 0.391 ns 1 ns
IBS EAST 107 146 0.181 ns 1 ns
WEST SOUTH 168 83 0.786 ns 1 ns
WEST EAST 168 146 0.472 ns 1 ns
SOUTH EAST 83 146 0.744 ns 1 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Basal_cell_carcinoma)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 −0.900 0.368 . white −0.630 0.529 . white −0.900 0.368 . white −1.810 0.070 . white
pct75.95 0.400 0.689 . white 0.420 0.674 . white 0.400 0.689 . white 0.260 0.795 . white
pct50.75 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white
pct25.50 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white
pct25 0.120 0.904 . white −0.040 0.968 . white 0.120 0.904 . white 0.630 0.529 . white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference