Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Bipolar_disorder)
rsID Risk allele Effect size
rs17418283 C 0.191
rs1042779 A 0.174
rs2242663 T 0.182
rs7250872 T 0.191
rs2537859 T 0.148
rs7427021 G 0.148
rs6990255 T 0.285
rs6494849 A 0.207
rs1035050 T 0.157
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Bipolar_disorder)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 168 0.069 0.017 0.001 0.066 0.071
SOUTH 83 0.065 0.019 0.002 0.061 0.069
EAST 146 0.067 0.016 0.001 0.064 0.069
Populations
IBS 107 0.068 0.019 0.002 0.065 0.072
PIR 397 0.067 0.017 0.001 0.066 0.069
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Bipolar_disorder)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 107 397 0.615 ns 1 ns
IBS WEST 107 168 0.811 ns 1 ns
IBS SOUTH 107 83 0.236 ns 1 ns
IBS EAST 107 146 0.508 ns 1 ns
WEST SOUTH 168 83 0.131 ns 1 ns
WEST EAST 168 146 0.314 ns 1 ns
SOUTH EAST 83 146 0.517 ns 1 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Bipolar_disorder)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 −1.050 0.294 . white −2.520 0.012 * −1.050 0.294 . white −2.510 0.012 *
pct75.95 −0.150 0.881 . white 2.190 0.029 * −0.150 0.881 . white 1.720 0.085 . white
pct50.75 0.050 0.960 . white −0.110 0.912 . white 0.050 0.960 . white −0.920 0.358 . white
pct25.50 0.580 0.562 . white 0.740 0.459 . white 0.580 0.562 . white 1.830 0.067 . white
pct25 0.170 0.865 . white −1.300 0.194 . white 0.170 0.865 . white −1.150 0.250 . white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference