Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Cardiovascular_disease_risk_factor)
rsID Risk allele Effect size
rs10911021 C 0.307
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Cardiovascular_disease_risk_factor)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 168 0.230 0.094 0.007 0.216 0.244
SOUTH 83 0.185 0.109 0.012 0.161 0.209
EAST 146 0.222 0.094 0.008 0.207 0.237
Populations
IBS 107 0.217 0.089 0.009 0.199 0.234
PIR 397 0.218 0.098 0.005 0.208 0.227
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Cardiovascular_disease_risk_factor)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 107 397 0.920000 ns 1.00000 ns
IBS WEST 107 168 0.255000 ns 1.00000 ns
IBS SOUTH 107 83 0.025400 * 0.25400 ns
IBS EAST 107 146 0.672000 ns 1.00000 ns
WEST SOUTH 168 83 0.000507 *** 0.00507 **
WEST EAST 168 146 0.443000 ns 1.00000 ns
SOUTH EAST 83 146 0.005650 ** 0.05650 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Cardiovascular_disease_risk_factor)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white
pct75.95 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white
pct50.75 −1.170 0.242 . white 1.640 0.101 . white −1.170 0.242 . white 0.770 0.441 . white
pct25.50 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white
pct25 1.170 0.242 . white −1.640 0.101 . white 1.170 0.242 . white −0.770 0.441 . white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference