Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Celiac_disease)
rsID	Risk allele	Effect size
rs17810546	G	0.307
rs2327832	G	0.207
rs13098911	T	0.262
rs11221332	T	0.191
rs802734	G	0.157
rs13003464	G	0.140
rs13010713	G	0.122
rs1893217	G	0.157
rs10806425	A	0.122
rs11712165	G	0.122
rs1033180	T	0.191
rs12727642	A	0.131
rs6974491	A	0.131
rs6806528	T	0.174
rs2298428	T	0.122
rs4899260	T	0.113
rs10936599	T	0.113
rs2762051	T	0.122
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Celiac_disease)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.032	0.010	0.001	0.030	0.033
SOUTH	83	0.033	0.010	0.001	0.031	0.035
EAST	146	0.032	0.011	0.001	0.030	0.034
Populations
IBS	107	0.031	0.010	0.001	0.029	0.033
PIR	397	0.032	0.010	0.001	0.031	0.033

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Celiac_disease)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.368	ns	1	ns
IBS	WEST	107	168	0.661	ns	1	ns
IBS	SOUTH	107	83	0.225	ns	1	ns
IBS	EAST	107	146	0.418	ns	1	ns
WEST	SOUTH	168	83	0.358	ns	1	ns
WEST	EAST	168	146	0.666	ns	1	ns
SOUTH	EAST	83	146	0.588	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Celiac_disease)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	1.820	0.069	.	white	1.440	0.150	.	white	1.820	0.069	.	white	1.660	0.097	.	white
pct75.95	−0.490	0.624	.	white	−0.370	0.711	.	white	−0.490	0.624	.	white	0.820	0.412	.	white
pct50.75	2.120	0.034	*		−0.440	0.660	.	white	2.120	0.034	*		−0.710	0.478	.	white
pct25.50	−1.100	0.271	.	white	1.570	0.116	.	white	−1.100	0.271	.	white	−0.010	0.992	.	white
pct25	−1.610	0.107	.	white	−1.520	0.129	.	white	−1.610	0.107	.	white	−0.840	0.401	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference