Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Cervical_cancer)
rsID	Risk allele	Effect size
rs9349379	A	0.262
rs6820391	A	0.215
rs12402265	A	0.207
rs11172113	T	0.199
rs6741522	A	0.231
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Cervical_cancer)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	103	0.086	0.028	0.003	0.081	0.092
SOUTH	45	0.089	0.036	0.005	0.078	0.099
EAST	57	0.086	0.036	0.005	0.077	0.096
Populations
IBS	53	0.086	0.030	0.004	0.078	0.095
PIR	205	0.087	0.032	0.002	0.082	0.091

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Cervical_cancer)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	53	205	0.947	ns	1	ns
IBS	WEST	53	103	0.975	ns	1	ns
IBS	SOUTH	53	45	0.742	ns	1	ns
IBS	EAST	53	57	0.975	ns	1	ns
WEST	SOUTH	103	45	0.686	ns	1	ns
WEST	EAST	103	57	0.997	ns	1	ns
SOUTH	EAST	45	57	0.715	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Cervical_cancer)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	1.190	0.234	.	white	0.910	0.363	.	white	1.190	0.234	.	white	1.290	0.197	.	white
pct75.95	−0.630	0.529	.	white	−2.150	0.032	*		−0.630	0.529	.	white	−1.800	0.072	.	white
pct50.75	1.920	0.055	.	white	2.330	0.020	*		1.920	0.055	.	white	1.090	0.276	.	white
pct25.50	−1.800	0.072	.	white	−0.150	0.881	.	white	−1.800	0.072	.	white	−0.660	0.509	.	white
pct25	0.030	0.976	.	white	−0.570	0.569	.	white	0.030	0.976	.	white	0.790	0.430	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference