Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Chronic_hepatitis_B_infection)
rsID	Risk allele	Effect size
rs9277535	A	0.419
rs12614	T	0.637
rs2856718	C	0.247
rs378352	A	0.231
rs2853953	A	0.385
rs422951	C	0.239
rs1419881	G	0.113
rs652888	G	0.131
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Chronic_hepatitis_B_infection)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.103	0.038	0.003	0.097	0.109
SOUTH	83	0.099	0.030	0.003	0.092	0.105
EAST	146	0.111	0.037	0.003	0.105	0.117
Populations
IBS	107	0.105	0.037	0.004	0.098	0.112
PIR	397	0.105	0.036	0.002	0.101	0.109

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Chronic_hepatitis_B_infection)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.9290	ns	1.000	ns
IBS	WEST	107	168	0.6880	ns	1.000	ns
IBS	SOUTH	107	83	0.2830	ns	1.000	ns
IBS	EAST	107	146	0.1750	ns	1.000	ns
WEST	SOUTH	168	83	0.4240	ns	1.000	ns
WEST	EAST	168	146	0.0498	*	0.498	ns
SOUTH	EAST	83	146	0.0167	*	0.167	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Chronic_hepatitis_B_infection)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.170	0.865	.	white	1.200	0.230	.	white	−0.170	0.865	.	white	1.630	0.103	.	white
pct75.95	−1.680	0.093	.	white	−1.290	0.197	.	white	−1.680	0.093	.	white	−0.450	0.653	.	white
pct50.75	0.620	0.535	.	white	0.100	0.920	.	white	0.620	0.535	.	white	0.710	0.478	.	white
pct25.50	0.310	0.757	.	white	−0.900	0.368	.	white	0.310	0.757	.	white	−0.360	0.719	.	white
pct25	0.680	0.497	.	white	1.370	0.171	.	white	0.680	0.497	.	white	−0.810	0.418	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference