Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Colorectal_cancer)
rsID	Risk allele	Effect size
rs174537	G	0.148
rs10795668	G	0.140
rs6983267	G	0.131
rs11196172	A	0.131
rs2423279	C	0.122
rs6687758	G	0.113
rs12603526	C	0.095
rs12412391	G	0.077
rs12309274	T	0.104
rs10411210	C	0.113
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Colorectal_cancer)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.056	0.011	0.001	0.054	0.057
SOUTH	83	0.055	0.010	0.001	0.053	0.057
EAST	146	0.052	0.012	0.001	0.050	0.054
Populations
IBS	107	0.056	0.011	0.001	0.054	0.058
PIR	397	0.054	0.011	0.001	0.053	0.055

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Colorectal_cancer)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.09960	ns	0.9960	ns
IBS	WEST	107	168	0.70900	ns	1.0000	ns
IBS	SOUTH	107	83	0.41000	ns	1.0000	ns
IBS	EAST	107	146	0.00407	**	0.0407	*
WEST	SOUTH	168	83	0.57900	ns	1.0000	ns
WEST	EAST	168	146	0.00473	**	0.0473	*
SOUTH	EAST	83	146	0.07390	ns	0.7390	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Colorectal_cancer)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.900	0.368	.	white	0.370	0.711	.	white	−0.900	0.368	.	white	−1.810	0.070	.	white
pct75.95	−0.710	0.478	.	white	−0.120	0.904	.	white	−0.710	0.478	.	white	−0.090	0.928	.	white
pct50.75	0.070	0.944	.	white	−0.950	0.342	.	white	0.070	0.944	.	white	−2.140	0.032	*
pct25.50	0.570	0.569	.	white	0.390	0.697	.	white	0.570	0.569	.	white	−0.750	0.453	.	white
pct25	0.480	0.631	.	white	0.510	0.610	.	white	0.480	0.631	.	white	3.540	0.000	***
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference