Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Coronary_artery_disease)
rsID	Risk allele	Effect size
rs10455872	G	0.270
rs9349379	G	0.104
rs7528419	A	0.104
rs28451064	A	0.131
rs6511720	G	0.131
rs7412	C	0.140
rs2246942	G	0.077
rs12202017	A	0.068
rs2107595	A	0.077
rs11556924	C	0.068
rs2071382	T	0.058
rs3918226	T	0.122
rs56170783	A	0.104
rs1887318	T	0.058
rs2681472	G	0.068
rs11591147	G	0.223
rs7623687	A	0.073
rs6841581	A	0.068
rs16986953	A	0.104
rs7500448	A	0.061
rs2244608	G	0.052
rs2306556	A	0.068
rs6909752	A	0.050
rs11057830	A	0.068
rs11191416	T	0.077
rs7678555	C	0.051
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Coronary_artery_disease)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.047	0.005	0.000	0.047	0.048
SOUTH	83	0.047	0.004	0.000	0.046	0.048
EAST	146	0.048	0.005	0.000	0.047	0.048
Populations
IBS	107	0.047	0.005	0.000	0.046	0.048
PIR	397	0.047	0.005	0.000	0.047	0.048

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Coronary_artery_disease)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.741	ns	1	ns
IBS	WEST	107	168	0.632	ns	1	ns
IBS	SOUTH	107	83	0.569	ns	1	ns
IBS	EAST	107	146	0.544	ns	1	ns
WEST	SOUTH	168	83	0.288	ns	1	ns
WEST	EAST	168	146	0.873	ns	1	ns
SOUTH	EAST	83	146	0.243	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Coronary_artery_disease)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−1.130	0.258	.	white	−0.940	0.347	.	white	−1.130	0.258	.	white	−0.890	0.373	.	white
pct75.95	0.130	0.897	.	white	1.220	0.222	.	white	0.130	0.897	.	white	1.770	0.077	.	white
pct50.75	0.310	0.757	.	white	0.080	0.936	.	white	0.310	0.757	.	white	0.840	0.401	.	white
pct25.50	0.090	0.928	.	white	0.370	0.711	.	white	0.090	0.928	.	white	−1.910	0.056	.	white
pct25	0.090	0.928	.	white	−1.080	0.280	.	white	0.090	0.928	.	white	−0.190	0.849	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference