Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Coronary_heart_disease)
rsID	Risk allele	Effect size
rs17114036	A	0.157
rs11556924	C	0.086
rs3825807	A	0.077
rs3798220	C	0.412
rs2895811	C	0.068
rs1746048	C	0.086
rs12936587	G	0.068
rs9982601	T	0.166
rs1231206	A	0.068
rs12413409	G	0.113
rs6725887	C	0.131
rs1122608	G	0.131
rs4773144	G	0.068
rs2306374	C	0.113
rs11206510	T	0.077
rs7808424	G	0.095
rs4937126	G	0.058
rs10933436	A	0.058
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Coronary_heart_disease)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.046	0.007	0.001	0.045	0.047
SOUTH	83	0.046	0.007	0.001	0.045	0.048
EAST	146	0.046	0.007	0.001	0.045	0.047
Populations
IBS	107	0.045	0.006	0.001	0.044	0.046
PIR	397	0.046	0.007	0.000	0.045	0.047

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Coronary_heart_disease)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.252	ns	1	ns
IBS	WEST	107	168	0.299	ns	1	ns
IBS	SOUTH	107	83	0.263	ns	1	ns
IBS	EAST	107	146	0.438	ns	1	ns
WEST	SOUTH	168	83	0.792	ns	1	ns
WEST	EAST	168	146	0.793	ns	1	ns
SOUTH	EAST	83	146	0.636	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Coronary_heart_disease)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	1.100	0.271	.	white	1.010	0.312	.	white	1.100	0.271	.	white	1.240	0.215	.	white
pct75.95	0.100	0.920	.	white	0.660	0.509	.	white	0.100	0.920	.	white	−0.040	0.968	.	white
pct50.75	0.010	0.992	.	white	0.290	0.772	.	white	0.010	0.992	.	white	−0.490	0.624	.	white
pct25.50	−1.340	0.180	.	white	−1.070	0.285	.	white	−1.340	0.180	.	white	−0.400	0.689	.	white
pct25	0.720	0.472	.	white	−0.320	0.749	.	white	0.720	0.472	.	white	0.310	0.757	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference