Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Crohn-s_disease)
rsID	Risk allele	Effect size
rs11209026	G	0.700
rs10781499	A	0.172
rs2188962	T	0.147
rs2836878	G	0.166
rs3197999	A	0.166
rs10761659	G	0.154
rs6871626	A	0.166
rs3024505	A	0.189
rs1801274	A	0.117
rs12946510	T	0.146
rs11741861	G	0.222
rs2413583	C	0.190
rs7554511	C	0.152
rs7608910	G	0.129
rs7134599	A	0.092
rs2823286	G	0.146
rs11564258	A	0.288
rs3091316	G	0.115
rs1893217	G	0.158
rs12942547	A	0.098
rs26528	C	0.094
rs6920220	A	0.097
rs3749171	T	0.127
rs1819333	T	0.078
rs6568421	G	0.103
rs17085007	C	0.101
rs11879191	G	0.128
rs1250546	A	0.092
rs12568930	T	0.091
rs2266959	T	0.100
rs529866	C	0.117
rs4845604	G	0.135
rs17293632	T	0.065
rs6545800	T	0.103
rs35675666	G	0.106
rs4246215	T	0.076
rs925255	C	0.088
rs17694108	A	0.095
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Crohn-s_disease)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.073	0.007	0.001	0.072	0.074
SOUTH	83	0.073	0.008	0.001	0.071	0.075
EAST	146	0.073	0.007	0.001	0.072	0.074
Populations
IBS	107	0.073	0.007	0.001	0.072	0.074
PIR	397	0.073	0.007	0.000	0.072	0.074

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Crohn-s_disease)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.940	ns	1	ns
IBS	WEST	107	168	0.996	ns	1	ns
IBS	SOUTH	107	83	0.999	ns	1	ns
IBS	EAST	107	146	0.857	ns	1	ns
WEST	SOUTH	168	83	0.998	ns	1	ns
WEST	EAST	168	146	0.836	ns	1	ns
SOUTH	EAST	83	146	0.867	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Crohn-s_disease)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	0.410	0.682	.	white	0.250	0.803	.	white	0.410	0.682	.	white	0.040	0.968	.	white
pct75.95	0.400	0.689	.	white	1.360	0.174	.	white	0.400	0.689	.	white	0.940	0.347	.	white
pct50.75	−0.050	0.960	.	white	−1.740	0.082	.	white	−0.050	0.960	.	white	0.010	0.992	.	white
pct25.50	−0.610	0.542	.	white	−0.120	0.904	.	white	−0.610	0.542	.	white	−1.380	0.168	.	white
pct25	0.120	0.904	.	white	0.420	0.674	.	white	0.120	0.904	.	white	0.480	0.631	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference