Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Disease-free_survival_in_breast_cancer)
rsID	Risk allele	Effect size
rs10825036	G	0.815
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Disease-free_survival_in_breast_cancer)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	103	0.301	0.302	0.030	0.242	0.360
SOUTH	45	0.254	0.265	0.039	0.174	0.333
EAST	57	0.186	0.232	0.031	0.124	0.247
Populations
IBS	53	0.215	0.205	0.028	0.159	0.272
PIR	205	0.258	0.279	0.019	0.220	0.297

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Disease-free_survival_in_breast_cancer)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	53	205	0.3010	ns	1.000	ns
IBS	WEST	53	103	0.0622	ns	0.622	ns
IBS	SOUTH	53	45	0.4850	ns	1.000	ns
IBS	EAST	53	57	0.5690	ns	1.000	ns
WEST	SOUTH	103	45	0.3300	ns	1.000	ns
WEST	EAST	103	57	0.0104	*	0.104	ns
SOUTH	EAST	45	57	0.2100	ns	1.000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Disease-free_survival_in_breast_cancer)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct75.95	2.220	0.026	*		3.240	0.001	**		2.220	0.026	*		1.380	0.168	.	white
pct50.75	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct25.50	−0.830	0.407	.	white	−1.670	0.095	.	white	−0.830	0.407	.	white	−1.500	0.134	.	white
pct25	−0.050	0.960	.	white	−0.410	0.682	.	white	−0.050	0.960	.	white	1.130	0.258	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference