Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Dupuytren-s_disease)
rsID	Risk allele	Effect size
rs16879765	T	0.630
rs2598107	T	0.390
rs629535	T	0.305
rs7291412	T	0.253
rs12342106	A	0.255
rs1042704	A	0.230
rs6102095	A	0.290
rs11672517	A	0.293
rs10866846	A	0.174
rs7524102	G	0.301
rs6016142	T	0.245
rs2306022	T	0.243
rs1509406	G	0.152
rs7071275	T	0.140
rs7866181	T	0.107
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Dupuytren-s_disease)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.057	0.021	0.002	0.054	0.060
SOUTH	83	0.056	0.021	0.002	0.051	0.060
EAST	146	0.056	0.020	0.002	0.053	0.059
Populations
IBS	107	0.056	0.018	0.002	0.053	0.060
PIR	397	0.056	0.020	0.001	0.054	0.058

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Dupuytren-s_disease)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.977	ns	1	ns
IBS	WEST	107	168	0.777	ns	1	ns
IBS	SOUTH	107	83	0.777	ns	1	ns
IBS	EAST	107	146	0.843	ns	1	ns
WEST	SOUTH	168	83	0.569	ns	1	ns
WEST	EAST	168	146	0.594	ns	1	ns
SOUTH	EAST	83	146	0.907	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Dupuytren-s_disease)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	0.410	0.682	.	white	0.460	0.646	.	white	0.410	0.682	.	white	−0.220	0.826	.	white
pct75.95	−0.640	0.522	.	white	0.050	0.960	.	white	−0.640	0.522	.	white	−0.140	0.889	.	white
pct50.75	0.200	0.841	.	white	−0.040	0.968	.	white	0.200	0.841	.	white	−0.490	0.624	.	white
pct25.50	−0.890	0.373	.	white	−1.830	0.067	.	white	−0.890	0.373	.	white	−0.200	0.841	.	white
pct25	1.120	0.263	.	white	1.560	0.119	.	white	1.120	0.263	.	white	0.950	0.342	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference