Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Endometrial_cancer)
rsID	Risk allele	Effect size
rs13328298	G	0.140
rs11841589	G	0.148
rs2498796	A	0.128
rs937213	C	0.105
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Endometrial_cancer)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	103	0.067	0.021	0.002	0.063	0.071
SOUTH	45	0.062	0.024	0.004	0.055	0.070
EAST	57	0.068	0.023	0.003	0.062	0.074
Populations
IBS	53	0.065	0.025	0.004	0.058	0.072
PIR	205	0.066	0.022	0.002	0.063	0.069

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Endometrial_cancer)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	53	205	0.621	ns	1	ns
IBS	WEST	53	103	0.551	ns	1	ns
IBS	SOUTH	53	45	0.639	ns	1	ns
IBS	EAST	53	57	0.383	ns	1	ns
WEST	SOUTH	103	45	0.273	ns	1	ns
WEST	EAST	103	57	0.690	ns	1	ns
SOUTH	EAST	45	57	0.190	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Endometrial_cancer)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.270	0.787	.	white	−1.760	0.078	.	white	−0.270	0.787	.	white	−0.540	0.589	.	white
pct75.95	−1.060	0.289	.	white	0.080	0.936	.	white	−1.060	0.289	.	white	−0.430	0.667	.	white
pct50.75	0.710	0.478	.	white	0.860	0.390	.	white	0.710	0.478	.	white	1.810	0.070	.	white
pct25.50	0.440	0.660	.	white	1.000	0.317	.	white	0.440	0.660	.	white	−0.670	0.503	.	white
pct25	−0.100	0.920	.	white	−1.320	0.187	.	white	−0.100	0.920	.	white	−0.660	0.509	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference