Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Endometriosis)
rsID	Risk allele	Effect size
rs10859871	C	0.182
rs7521902	A	0.174
rs1537377	C	0.140
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Endometriosis)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	103	0.041	0.026	0.003	0.036	0.046
SOUTH	45	0.048	0.030	0.004	0.039	0.057
EAST	57	0.042	0.031	0.004	0.034	0.050
Populations
IBS	53	0.050	0.030	0.004	0.042	0.058
PIR	205	0.043	0.028	0.002	0.039	0.046

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Endometriosis)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	53	205	0.1060	ns	1.000	ns
IBS	WEST	53	103	0.0591	ns	0.591	ns
IBS	SOUTH	53	45	0.7710	ns	1.000	ns
IBS	EAST	53	57	0.1540	ns	1.000	ns
WEST	SOUTH	103	45	0.1450	ns	1.000	ns
WEST	EAST	103	57	0.7750	ns	1.000	ns
SOUTH	EAST	45	57	0.2840	ns	1.000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Endometriosis)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.440	0.660	.	white	0.030	0.976	.	white	−0.440	0.660	.	white	0.370	0.711	.	white
pct75.95	1.410	0.159	.	white	−1.710	0.087	.	white	1.410	0.159	.	white	0.040	0.968	.	white
pct50.75	−2.810	0.005	**		−1.550	0.121	.	white	−2.810	0.005	**		−3.230	0.001	**
pct25.50	1.170	0.242	.	white	2.550	0.011	*		1.170	0.242	.	white	2.110	0.035	*
pct25	0.690	0.490	.	white	0.490	0.624	.	white	0.690	0.490	.	white	1.090	0.276	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference