Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Ewing_sarcoma)
rsID	Risk allele	Effect size
rs9430161	G	0.788
rs224278	C	0.507
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Ewing_sarcoma)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.451	0.137	0.011	0.430	0.472
SOUTH	83	0.462	0.152	0.017	0.429	0.495
EAST	146	0.475	0.144	0.012	0.451	0.498
Populations
IBS	107	0.461	0.143	0.014	0.433	0.488
PIR	397	0.462	0.143	0.007	0.448	0.476

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Ewing_sarcoma)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.949	ns	1	ns
IBS	WEST	107	168	0.577	ns	1	ns
IBS	SOUTH	107	83	0.975	ns	1	ns
IBS	EAST	107	146	0.452	ns	1	ns
WEST	SOUTH	168	83	0.583	ns	1	ns
WEST	EAST	168	146	0.146	ns	1	ns
SOUTH	EAST	83	146	0.508	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Ewing_sarcoma)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct75.95	0.310	0.757	.	white	−1.370	0.171	.	white	0.310	0.757	.	white	−0.010	0.992	.	white
pct50.75	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct25.50	−0.590	0.555	.	white	0.960	0.337	.	white	−0.590	0.555	.	white	1.230	0.219	.	white
pct25	0.350	0.726	.	white	0.140	0.889	.	white	0.350	0.726	.	white	−1.410	0.159	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference