Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Follicular_lymphoma)
rsID	Risk allele	Effect size
rs12195582	T	0.577
rs17749561	G	0.293
rs13254990	T	0.166
rs2681416	A	0.148
rs3751913	C	0.207
rs11082438	G	0.285
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Follicular_lymphoma)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.154	0.044	0.003	0.147	0.161
SOUTH	83	0.147	0.037	0.004	0.138	0.155
EAST	146	0.152	0.043	0.004	0.145	0.159
Populations
IBS	107	0.150	0.041	0.004	0.142	0.158
PIR	397	0.152	0.042	0.002	0.148	0.156

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Follicular_lymphoma)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.680	ns	1	ns
IBS	WEST	107	168	0.441	ns	1	ns
IBS	SOUTH	107	83	0.586	ns	1	ns
IBS	EAST	107	146	0.650	ns	1	ns
WEST	SOUTH	168	83	0.193	ns	1	ns
WEST	EAST	168	146	0.740	ns	1	ns
SOUTH	EAST	83	146	0.318	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Follicular_lymphoma)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.170	0.865	.	white	1.540	0.124	.	white	−0.170	0.865	.	white	1.240	0.215	.	white
pct75.95	−0.490	0.624	.	white	0.360	0.719	.	white	−0.490	0.624	.	white	0.050	0.960	.	white
pct50.75	−0.770	0.441	.	white	−0.850	0.395	.	white	−0.770	0.441	.	white	−0.880	0.379	.	white
pct25.50	0.880	0.379	.	white	−0.620	0.535	.	white	0.880	0.379	.	white	−0.520	0.603	.	white
pct25	0.310	0.757	.	white	0.310	0.757	.	white	0.310	0.757	.	white	0.730	0.465	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference