Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Follicular_lymphoma)
rsID Risk allele Effect size
rs12195582 T 0.577
rs17749561 G 0.293
rs13254990 T 0.166
rs2681416 A 0.148
rs3751913 C 0.207
rs11082438 G 0.285
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Follicular_lymphoma)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 168 0.154 0.044 0.003 0.147 0.161
SOUTH 83 0.147 0.037 0.004 0.138 0.155
EAST 146 0.152 0.043 0.004 0.145 0.159
Populations
IBS 107 0.150 0.041 0.004 0.142 0.158
PIR 397 0.152 0.042 0.002 0.148 0.156
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Follicular_lymphoma)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 107 397 0.680 ns 1 ns
IBS WEST 107 168 0.441 ns 1 ns
IBS SOUTH 107 83 0.586 ns 1 ns
IBS EAST 107 146 0.650 ns 1 ns
WEST SOUTH 168 83 0.193 ns 1 ns
WEST EAST 168 146 0.740 ns 1 ns
SOUTH EAST 83 146 0.318 ns 1 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Follicular_lymphoma)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 −0.170 0.865 . white 1.540 0.124 . white −0.170 0.865 . white 1.240 0.215 . white
pct75.95 −0.490 0.624 . white 0.360 0.719 . white −0.490 0.624 . white 0.050 0.960 . white
pct50.75 −0.770 0.441 . white −0.850 0.395 . white −0.770 0.441 . white −0.880 0.379 . white
pct25.50 0.880 0.379 . white −0.620 0.535 . white 0.880 0.379 . white −0.520 0.603 . white
pct25 0.310 0.757 . white 0.310 0.757 . white 0.310 0.757 . white 0.730 0.465 . white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference