Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Gout)
rsID	Risk allele	Effect size
rs3114020	C	0.637
rs4766566	T	0.412
rs1165176	G	0.351
rs11758351	G	0.336
rs4073582	G	0.457
rs11733284	A	0.215
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Gout)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.167	0.057	0.004	0.159	0.176
SOUTH	83	0.156	0.055	0.006	0.144	0.168
EAST	146	0.167	0.055	0.005	0.158	0.176
Populations
IBS	107	0.161	0.059	0.006	0.149	0.172
PIR	397	0.165	0.056	0.003	0.159	0.170

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Gout)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.467	ns	1	ns
IBS	WEST	107	168	0.317	ns	1	ns
IBS	SOUTH	107	83	0.603	ns	1	ns
IBS	EAST	107	146	0.362	ns	1	ns
WEST	SOUTH	168	83	0.136	ns	1	ns
WEST	EAST	168	146	0.945	ns	1	ns
SOUTH	EAST	83	146	0.163	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Gout)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−2.370	0.018	*		0.000	1.000	.	white	−2.370	0.018	*		−0.350	0.726	.	white
pct75.95	−0.010	0.992	.	white	−0.190	0.849	.	white	−0.010	0.992	.	white	−0.410	0.682	.	white
pct50.75	0.810	0.418	.	white	0.670	0.503	.	white	0.810	0.418	.	white	0.950	0.342	.	white
pct25.50	1.810	0.070	.	white	1.710	0.087	.	white	1.810	0.070	.	white	2.320	0.020	*
pct25	−1.380	0.168	.	white	−2.050	0.040	*		−1.380	0.168	.	white	−2.630	0.009	**
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference