Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Graves_disease)
rsID	Risk allele	Effect size
rs2281388	A	0.495
rs4947296	C	0.571
rs6457617	T	0.336
rs12101261	T	0.300
rs3761959	T	0.207
rs9355610	G	0.174
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Graves_disease)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.089	0.039	0.003	0.083	0.095
SOUTH	83	0.087	0.034	0.004	0.079	0.094
EAST	146	0.084	0.038	0.003	0.078	0.090
Populations
IBS	107	0.092	0.038	0.004	0.085	0.100
PIR	397	0.087	0.037	0.002	0.083	0.091

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Graves_disease)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.1790	ns	1.000	ns
IBS	WEST	107	168	0.5170	ns	1.000	ns
IBS	SOUTH	107	83	0.2900	ns	1.000	ns
IBS	EAST	107	146	0.0876	ns	0.876	ns
WEST	SOUTH	168	83	0.5780	ns	1.000	ns
WEST	EAST	168	146	0.2250	ns	1.000	ns
SOUTH	EAST	83	146	0.6490	ns	1.000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Graves_disease)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−1.550	0.121	.	white	−0.710	0.478	.	white	−1.550	0.121	.	white	−0.890	0.373	.	white
pct75.95	0.150	0.881	.	white	0.120	0.904	.	white	0.150	0.881	.	white	−0.510	0.610	.	white
pct50.75	−0.660	0.509	.	white	−0.390	0.697	.	white	−0.660	0.509	.	white	−1.080	0.280	.	white
pct25.50	0.380	0.704	.	white	−0.850	0.395	.	white	0.380	0.704	.	white	0.260	0.795	.	white
pct25	0.960	0.337	.	white	1.490	0.136	.	white	0.960	0.337	.	white	1.710	0.087	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference