rsID	Risk allele	Effect size
Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Immunoglobulin_light_chain_AL_amyloidosis)
rs11219122	C	0.223
rs4792800	G	0.307
rs2273156	C	0.255
rs35629860	A	0.231
Effect size: LN(OR)

	count	mean	sd	se	lower.ci	upper.ci
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Immunoglobulin_light_chain_AL_amyloidosis)
Pyrenean regions
WEST	168	0.060	0.038	0.003	0.054	0.065
SOUTH	83	0.055	0.033	0.004	0.048	0.062
EAST	146	0.054	0.036	0.003	0.048	0.060
Populations
IBS	107	0.052	0.034	0.003	0.046	0.059
PIR	397	0.056	0.036	0.002	0.053	0.060

group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Immunoglobulin_light_chain_AL_amyloidosis)
IBS	PIR	107	397	0.305	ns	1	ns
IBS	WEST	107	168	0.109	ns	1	ns
IBS	SOUTH	107	83	0.682	ns	1	ns
IBS	EAST	107	146	0.743	ns	1	ns
WEST	SOUTH	168	83	0.303	ns	1	ns
WEST	EAST	168	146	0.167	ns	1	ns
SOUTH	EAST	83	146	0.895	ns	1	ns
* p < .05, p < .01, * p < .001

Percentile rank	PIR				WEST				SOUTH				EAST
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Immunoglobulin_light_chain_AL_amyloidosis)
Percentile rank	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−1.090	0.276	.	white	0.320	0.749	.	white	−1.090	0.276	.	white	−0.840	0.401	.	white
pct75.95	0.610	0.542	.	white	1.470	0.142	.	white	0.610	0.542	.	white	0.940	0.347	.	white
pct50.75	0.550	0.582	.	white	0.360	0.719	.	white	0.550	0.582	.	white	0.570	0.569	.	white
pct25.50	0.960	0.337	.	white	−0.190	0.849	.	white	0.960	0.337	.	white	0.260	0.795	.	white
pct25	−1.350	0.177	.	white	−1.580	0.114	.	white	−1.350	0.177	.	white	−1.130	0.258	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, p < .01, * p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference