Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Immunoglobulin_light_chain_AL_amyloidosis)
rsID Risk allele Effect size
rs11219122 C 0.223
rs4792800 G 0.307
rs2273156 C 0.255
rs35629860 A 0.231
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Immunoglobulin_light_chain_AL_amyloidosis)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 168 0.060 0.038 0.003 0.054 0.065
SOUTH 83 0.055 0.033 0.004 0.048 0.062
EAST 146 0.054 0.036 0.003 0.048 0.060
Populations
IBS 107 0.052 0.034 0.003 0.046 0.059
PIR 397 0.056 0.036 0.002 0.053 0.060
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Immunoglobulin_light_chain_AL_amyloidosis)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 107 397 0.305 ns 1 ns
IBS WEST 107 168 0.109 ns 1 ns
IBS SOUTH 107 83 0.682 ns 1 ns
IBS EAST 107 146 0.743 ns 1 ns
WEST SOUTH 168 83 0.303 ns 1 ns
WEST EAST 168 146 0.167 ns 1 ns
SOUTH EAST 83 146 0.895 ns 1 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Immunoglobulin_light_chain_AL_amyloidosis)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 −1.090 0.276 . white 0.320 0.749 . white −1.090 0.276 . white −0.840 0.401 . white
pct75.95 0.610 0.542 . white 1.470 0.142 . white 0.610 0.542 . white 0.940 0.347 . white
pct50.75 0.550 0.582 . white 0.360 0.719 . white 0.550 0.582 . white 0.570 0.569 . white
pct25.50 0.960 0.337 . white −0.190 0.849 . white 0.960 0.337 . white 0.260 0.795 . white
pct25 −1.350 0.177 . white −1.580 0.114 . white −1.350 0.177 . white −1.130 0.258 . white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference