Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Inflammatory_bowel_disease_early_onset)
rsID Risk allele Effect size
rs8049439 C 0.131
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Inflammatory_bowel_disease_early_onset)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 168 0.047 0.044 0.003 0.040 0.054
SOUTH 83 0.031 0.040 0.004 0.022 0.040
EAST 146 0.045 0.040 0.003 0.039 0.052
Populations
IBS 107 0.040 0.042 0.004 0.032 0.048
PIR 397 0.043 0.042 0.002 0.039 0.047
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Inflammatory_bowel_disease_early_onset)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 107 397 0.58500 ns 1.0000 ns
IBS WEST 107 168 0.21900 ns 1.0000 ns
IBS SOUTH 107 83 0.11700 ns 1.0000 ns
IBS EAST 107 146 0.35800 ns 1.0000 ns
WEST SOUTH 168 83 0.00453 ** 0.0453 *
WEST EAST 168 146 0.75600 ns 1.0000 ns
SOUTH EAST 83 146 0.01180 * 0.1180 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Inflammatory_bowel_disease_early_onset)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white
pct75.95 −0.620 0.535 . white 1.060 0.289 . white −0.620 0.535 . white −0.260 0.795 . white
pct50.75 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white
pct25.50 −1.380 0.168 . white 0.250 0.803 . white −1.380 0.168 . white 1.450 0.147 . white
pct25 1.680 0.093 . white −0.920 0.358 . white 1.680 0.093 . white −1.330 0.184 . white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference