Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Interstitial_lung_disease)
rsID	Risk allele	Effect size
rs2076295	G	0.358
rs1981997	G	0.344
rs6793295	C	0.262
rs12610495	G	0.255
rs2034650	A	0.262
rs4727443	C	0.262
rs1379326	C	0.577
rs2441727	G	0.300
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Interstitial_lung_disease)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.129	0.036	0.003	0.124	0.135
SOUTH	83	0.128	0.044	0.005	0.119	0.138
EAST	146	0.129	0.037	0.003	0.123	0.135
Populations
IBS	107	0.125	0.040	0.004	0.117	0.132
PIR	397	0.129	0.038	0.002	0.125	0.133

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Interstitial_lung_disease)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.325	ns	1	ns
IBS	WEST	107	168	0.321	ns	1	ns
IBS	SOUTH	107	83	0.540	ns	1	ns
IBS	EAST	107	146	0.436	ns	1	ns
WEST	SOUTH	168	83	0.805	ns	1	ns
WEST	EAST	168	146	0.835	ns	1	ns
SOUTH	EAST	83	146	0.944	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Interstitial_lung_disease)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	1.070	0.285	.	white	0.410	0.682	.	white	1.070	0.285	.	white	0.150	0.881	.	white
pct75.95	−0.320	0.749	.	white	−0.430	0.667	.	white	−0.320	0.749	.	white	−0.770	0.441	.	white
pct50.75	−0.430	0.667	.	white	1.070	0.285	.	white	−0.430	0.667	.	white	1.480	0.139	.	white
pct25.50	0.530	0.596	.	white	0.350	0.726	.	white	0.530	0.596	.	white	−0.320	0.749	.	white
pct25	−0.380	0.704	.	white	−1.180	0.238	.	white	−0.380	0.704	.	white	−0.520	0.603	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference