Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Intracranial_aneurysm)
rsID	Risk allele	Effect size
rs9298506	A	0.247
rs12413409	G	0.255
rs9315204	T	0.182
rs1504749	C	0.157
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Intracranial_aneurysm)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.131	0.029	0.002	0.127	0.136
SOUTH	83	0.130	0.028	0.003	0.124	0.136
EAST	146	0.130	0.027	0.002	0.125	0.134
Populations
IBS	107	0.123	0.025	0.002	0.118	0.128
PIR	397	0.131	0.028	0.001	0.128	0.133

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Intracranial_aneurysm)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.00894	**	0.0894	ns
IBS	WEST	107	168	0.01080	*	0.1080	ns
IBS	SOUTH	107	83	0.05910	ns	0.5910	ns
IBS	EAST	107	146	0.04500	*	0.4500	ns
WEST	SOUTH	168	83	0.76900	ns	1.0000	ns
WEST	EAST	168	146	0.59400	ns	1.0000	ns
SOUTH	EAST	83	146	0.87900	ns	1.0000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Intracranial_aneurysm)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	2.280	0.023	*		1.910	0.056	.	white	2.280	0.023	*		0.710	0.478	.	white
pct75.95	0.790	0.430	.	white	1.590	0.112	.	white	0.790	0.430	.	white	0.690	0.490	.	white
pct50.75	−0.560	0.575	.	white	0.140	0.889	.	white	−0.560	0.575	.	white	1.110	0.267	.	white
pct25.50	0.460	0.646	.	white	0.480	0.631	.	white	0.460	0.646	.	white	0.530	0.596	.	white
pct25	−1.270	0.204	.	white	−2.490	0.013	*		−1.270	0.204	.	white	−2.280	0.023	*
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference