Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Ischemic_stroke_cardioembolic)
rsID	Risk allele	Effect size
rs2200733	TRUE	0.315
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Ischemic_stroke_cardioembolic)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.031	0.067	0.005	0.021	0.041
SOUTH	83	0.047	0.084	0.009	0.029	0.066
EAST	146	0.027	0.062	0.005	0.017	0.037
Populations
IBS	107	0.060	0.093	0.009	0.042	0.078
PIR	397	0.033	0.070	0.004	0.026	0.040

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Ischemic_stroke_cardioembolic)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.000574	***	0.00574	**
IBS	WEST	107	168	0.001140	**	0.01140	*
IBS	SOUTH	107	83	0.226000	ns	1.00000	ns
IBS	EAST	107	146	0.000334	***	0.00334	**
WEST	SOUTH	168	83	0.091600	ns	0.91600	ns
WEST	EAST	168	146	0.630000	ns	1.00000	ns
SOUTH	EAST	83	146	0.041200	*	0.41200	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Ischemic_stroke_cardioembolic)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.640	0.522	.	white	−2.120	0.034	*		−0.640	0.522	.	white	−2.360	0.018	*
pct75.95	−0.660	0.509	.	white	−1.950	0.051	.		−0.660	0.509	.	white	−2.210	0.027	*
pct50.75	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct25.50	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct25	0.930	0.352	.	white	2.700	0.007	**		0.930	0.352	.	white	3.020	0.003	**
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference