Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Knee_osteoarthritis)
rsID	Risk allele	Effect size
rs117018441	T	1.773
rs10843013	C	0.131
rs12209223	A	0.148
rs13283416	G	0.095
rs1800562	G	0.668
rs4733724	A	0.104
rs10760442	G	0.086
rs1997995	G	0.086
rs4252548	T	0.262
rs2785988	A	0.077
rs10896015	G	0.086
rs11764536	C	0.231
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Knee_osteoarthritis)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.083	0.015	0.001	0.081	0.086
SOUTH	83	0.085	0.018	0.002	0.082	0.089
EAST	146	0.086	0.014	0.001	0.084	0.088
Populations
IBS	107	0.085	0.018	0.002	0.081	0.088
PIR	397	0.085	0.015	0.001	0.083	0.086

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Knee_osteoarthritis)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.905	ns	1	ns
IBS	WEST	107	168	0.560	ns	1	ns
IBS	SOUTH	107	83	0.691	ns	1	ns
IBS	EAST	107	146	0.503	ns	1	ns
WEST	SOUTH	168	83	0.332	ns	1	ns
WEST	EAST	168	146	0.165	ns	1	ns
SOUTH	EAST	83	146	0.844	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Knee_osteoarthritis)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.240	0.810	.	white	−0.810	0.418	.	white	−0.240	0.810	.	white	0.400	0.689	.	white
pct75.95	0.820	0.412	.	white	1.140	0.254	.	white	0.820	0.412	.	white	0.400	0.689	.	white
pct50.75	−0.080	0.936	.	white	0.200	0.841	.	white	−0.080	0.936	.	white	0.960	0.337	.	white
pct25.50	−0.890	0.373	.	white	−1.470	0.142	.	white	−0.890	0.373	.	white	−1.060	0.289	.	white
pct25	0.380	0.704	.	white	0.610	0.542	.	white	0.380	0.704	.	white	−0.490	0.624	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference