Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Lung_adenocarcinoma)
rsID	Risk allele	Effect size
rs1051730	A	0.270
rs3117582	G	0.199
rs31489	C	0.113
rs4324798	A	0.148
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Lung_adenocarcinoma)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.048	0.029	0.002	0.043	0.052
SOUTH	83	0.048	0.030	0.003	0.041	0.054
EAST	146	0.051	0.030	0.003	0.046	0.056
Populations
IBS	107	0.055	0.029	0.003	0.050	0.061
PIR	397	0.049	0.030	0.001	0.046	0.052

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Lung_adenocarcinoma)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.0471	*	0.471	ns
IBS	WEST	107	168	0.0385	*	0.385	ns
IBS	SOUTH	107	83	0.0793	ns	0.793	ns
IBS	EAST	107	146	0.2460	ns	1.000	ns
WEST	SOUTH	168	83	0.9960	ns	1.000	ns
WEST	EAST	168	146	0.3380	ns	1.000	ns
SOUTH	EAST	83	146	0.4270	ns	1.000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Lung_adenocarcinoma)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.750	0.453	.	white	−1.440	0.150	.	white	−0.750	0.453	.	white	−0.890	0.373	.	white
pct75.95	−0.710	0.478	.	white	−0.120	0.904	.	white	−0.710	0.478	.	white	0.570	0.569	.	white
pct50.75	−0.740	0.459	.	white	−1.320	0.187	.	white	−0.740	0.459	.	white	−0.910	0.363	.	white
pct25.50	−0.050	0.960	.	white	−0.560	0.575	.	white	−0.050	0.960	.	white	−0.860	0.390	.	white
pct25	1.730	0.084	.	white	2.430	0.015	*		1.730	0.084	.	white	1.590	0.112	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference