Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Male-pattern_baldness)
rsID	Risk allele	Effect size
rs2497938	T	0.788
rs6047844	T	0.470
rs9287638	A	0.270
rs2073963	G	0.255
rs12565727	A	0.285
rs12373124	T	0.285
rs6945541	C	0.239
rs10502861	C	0.247
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Male-pattern_baldness)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	65	0.188	0.040	0.005	0.178	0.198
SOUTH	38	0.209	0.040	0.006	0.196	0.222
EAST	89	0.195	0.045	0.005	0.185	0.204
Populations
IBS	54	0.186	0.037	0.005	0.176	0.196
PIR	192	0.195	0.043	0.003	0.189	0.201

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Male-pattern_baldness)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	54	192	0.1410	ns	1.000	ns
IBS	WEST	54	65	0.7440	ns	1.000	ns
IBS	SOUTH	54	38	0.0103	*	0.103	ns
IBS	EAST	54	89	0.2180	ns	1.000	ns
WEST	SOUTH	65	38	0.0179	*	0.179	ns
WEST	EAST	65	89	0.3490	ns	1.000	ns
SOUTH	EAST	38	89	0.0870	ns	0.870	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Male-pattern_baldness)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	2.100	0.036	*		1.850	0.064	.	white	2.100	0.036	*		1.950	0.051	.
pct75.95	1.650	0.099	.	white	0.310	0.757	.	white	1.650	0.099	.	white	0.970	0.332	.	white
pct50.75	−0.180	0.857	.	white	−2.300	0.021	*		−0.180	0.857	.	white	−1.590	0.112	.	white
pct25.50	−1.830	0.067	.	white	0.580	0.562	.	white	−1.830	0.067	.	white	0.280	0.779	.	white
pct25	−0.540	0.589	.	white	0.580	0.562	.	white	−0.540	0.589	.	white	−0.470	0.638	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference