Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Mesial_temporal_lobe_epilepsy_with_hippocampal_sclerosis)
rsID	Risk allele	Effect size
rs7587026	A	0.215
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Mesial_temporal_lobe_epilepsy_with_hippocampal_sclerosis)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.063	0.073	0.006	0.052	0.074
SOUTH	83	0.057	0.059	0.006	0.044	0.070
EAST	146	0.046	0.063	0.005	0.036	0.057
Populations
IBS	107	0.059	0.068	0.007	0.046	0.072
PIR	397	0.056	0.067	0.003	0.049	0.062

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Mesial_temporal_lobe_epilepsy_with_hippocampal_sclerosis)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.6310	ns	1.000	ns
IBS	WEST	107	168	0.6230	ns	1.000	ns
IBS	SOUTH	107	83	0.8150	ns	1.000	ns
IBS	EAST	107	146	0.1300	ns	1.000	ns
WEST	SOUTH	168	83	0.4790	ns	1.000	ns
WEST	EAST	168	146	0.0252	*	0.252	ns
SOUTH	EAST	83	146	0.2490	ns	1.000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Mesial_temporal_lobe_epilepsy_with_hippocampal_sclerosis)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct75.95	−1.550	0.121	.	white	0.890	0.373	.	white	−1.550	0.121	.	white	−0.890	0.373	.	white
pct50.75	1.100	0.271	.	white	−0.450	0.653	.	white	1.100	0.271	.	white	−1.080	0.280	.	white
pct25.50	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct25	−0.400	0.689	.	white	−0.090	0.928	.	white	−0.400	0.689	.	white	1.480	0.139	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference