Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Mortality_in_heart_failure)
rsID	Risk allele	Effect size
rs12638540	G	0.425
rs2125623	C	0.207
rs4528684	T	0.351
rs7965445	A	0.262
rs4979906	G	0.207
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Mortality_in_heart_failure)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.050	0.024	0.002	0.046	0.054
SOUTH	83	0.054	0.024	0.003	0.048	0.059
EAST	146	0.051	0.028	0.002	0.047	0.056
Populations
IBS	107	0.053	0.028	0.003	0.048	0.059
PIR	397	0.051	0.026	0.001	0.049	0.054

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Mortality_in_heart_failure)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.506	ns	1	ns
IBS	WEST	107	168	0.348	ns	1	ns
IBS	SOUTH	107	83	0.878	ns	1	ns
IBS	EAST	107	146	0.550	ns	1	ns
WEST	SOUTH	168	83	0.301	ns	1	ns
WEST	EAST	168	146	0.724	ns	1	ns
SOUTH	EAST	83	146	0.473	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Mortality_in_heart_failure)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.640	0.522	.	white	−0.550	0.582	.	white	−0.640	0.522	.	white	−0.290	0.772	.	white
pct75.95	−0.330	0.741	.	white	−1.410	0.159	.	white	−0.330	0.741	.	white	−0.470	0.638	.	white
pct50.75	1.560	0.119	.	white	0.810	0.418	.	white	1.560	0.119	.	white	0.780	0.435	.	white
pct25.50	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct25	−0.860	0.390	.	white	0.530	0.596	.	white	−0.860	0.390	.	white	−0.190	0.849	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference