Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Multiple_myeloma)
rsID	Risk allele	Effect size
rs6599175	C	0.392
rs139371	T	0.315
rs2235544	A	0.262
rs2302777	A	0.270
rs11157317	T	0.255
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Multiple_myeloma)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.124	0.041	0.003	0.118	0.130
SOUTH	83	0.110	0.043	0.005	0.101	0.120
EAST	146	0.125	0.046	0.004	0.117	0.132
Populations
IBS	107	0.122	0.040	0.004	0.114	0.129
PIR	397	0.121	0.044	0.002	0.117	0.126

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Multiple_myeloma)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.9350	ns	1.000	ns
IBS	WEST	107	168	0.7000	ns	1.000	ns
IBS	SOUTH	107	83	0.0679	ns	0.679	ns
IBS	EAST	107	146	0.5660	ns	1.000	ns
WEST	SOUTH	168	83	0.0191	*	0.191	ns
WEST	EAST	168	146	0.8210	ns	1.000	ns
SOUTH	EAST	83	146	0.0134	*	0.134	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Multiple_myeloma)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−0.040	0.968	.	white	0.620	0.535	.	white	−0.040	0.968	.	white	0.860	0.390	.	white
pct75.95	−1.320	0.187	.	white	0.170	0.865	.	white	−1.320	0.187	.	white	0.260	0.795	.	white
pct50.75	−1.180	0.238	.	white	−0.160	0.873	.	white	−1.180	0.238	.	white	0.500	0.617	.	white
pct25.50	0.750	0.453	.	white	0.610	0.542	.	white	0.750	0.453	.	white	−1.150	0.250	.	white
pct25	1.460	0.144	.	white	−0.970	0.332	.	white	1.460	0.144	.	white	−0.100	0.920	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference