Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Multiple_sclerosis)
rsID	Risk allele	Effect size
rs1800693	C	0.182
rs2300747	A	0.262
rs17445836	G	0.223
rs2104286	T	0.140
rs11865121	C	0.140
rs1250540	G	0.113
rs6897932	C	0.113
rs4149584	T	0.457
rs4680534	C	0.113
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Multiple_sclerosis)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.095	0.015	0.001	0.093	0.097
SOUTH	83	0.094	0.014	0.002	0.091	0.097
EAST	146	0.094	0.017	0.001	0.091	0.097
Populations
IBS	107	0.095	0.017	0.002	0.092	0.098
PIR	397	0.094	0.016	0.001	0.093	0.096

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Multiple_sclerosis)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.751	ns	1	ns
IBS	WEST	107	168	0.994	ns	1	ns
IBS	SOUTH	107	83	0.667	ns	1	ns
IBS	EAST	107	146	0.642	ns	1	ns
WEST	SOUTH	168	83	0.634	ns	1	ns
WEST	EAST	168	146	0.595	ns	1	ns
SOUTH	EAST	83	146	0.978	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Multiple_sclerosis)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−1.820	0.069	.	white	−1.130	0.258	.	white	−1.820	0.069	.	white	−0.600	0.549	.	white
pct75.95	−1.180	0.238	.	white	−1.600	0.110	.	white	−1.180	0.238	.	white	−0.620	0.535	.	white
pct50.75	1.360	0.174	.	white	1.310	0.190	.	white	1.360	0.174	.	white	−0.050	0.960	.	white
pct25.50	1.810	0.070	.	white	2.020	0.043	*		1.810	0.070	.	white	1.380	0.168	.	white
pct25	−1.080	0.280	.	white	−1.240	0.215	.	white	−1.080	0.280	.	white	−0.320	0.749	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference