Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Myocardial_infarction)
rsID	Risk allele	Effect size
rs9349379	G	0.131
rs10455872	G	0.285
rs7528419	A	0.113
rs1332329	C	0.077
rs28451064	A	0.131
rs9970807	C	0.122
rs2681472	G	0.077
rs2505083	C	0.058
rs72689147	G	0.068
rs55791371	A	0.104
rs1544935	T	0.077
rs56131196	A	0.086
rs11556924	C	0.077
rs55940034	G	0.068
rs1004467	A	0.077
rs11206510	T	0.077
rs16986953	A	0.086
rs9914266	C	0.049
rs35895680	C	0.058
rs7212798	C	0.077
rs17678683	G	0.095
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Myocardial_infarction)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.041	0.006	0.000	0.040	0.042
SOUTH	83	0.040	0.006	0.001	0.039	0.042
EAST	146	0.042	0.005	0.000	0.041	0.042
Populations
IBS	107	0.041	0.006	0.001	0.040	0.042
PIR	397	0.041	0.006	0.000	0.040	0.042

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Myocardial_infarction)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.618	ns	1	ns
IBS	WEST	107	168	0.887	ns	1	ns
IBS	SOUTH	107	83	0.720	ns	1	ns
IBS	EAST	107	146	0.216	ns	1	ns
WEST	SOUTH	168	83	0.601	ns	1	ns
WEST	EAST	168	146	0.216	ns	1	ns
SOUTH	EAST	83	146	0.127	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Myocardial_infarction)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	1.660	0.097	.	white	0.620	0.535	.	white	1.660	0.097	.	white	−0.130	0.897	.	white
pct75.95	−2.190	0.029	*		−0.750	0.453	.	white	−2.190	0.029	*		0.830	0.407	.	white
pct50.75	0.160	0.873	.	white	0.130	0.897	.	white	0.160	0.873	.	white	0.310	0.757	.	white
pct25.50	0.120	0.904	.	white	0.850	0.395	.	white	0.120	0.904	.	white	−0.010	0.992	.	white
pct25	0.640	0.522	.	white	−0.610	0.542	.	white	0.640	0.522	.	white	−1.080	0.280	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference