Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Narcolepsy)
rsID	Risk allele	Effect size
rs7553711	C	0.285
rs10995245	A	0.182
rs306336	G	0.501
rs1027327	G	0.307
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Narcolepsy)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.053	0.036	0.003	0.047	0.058
SOUTH	83	0.047	0.031	0.003	0.040	0.053
EAST	146	0.049	0.034	0.003	0.044	0.055
Populations
IBS	107	0.055	0.037	0.004	0.048	0.062
PIR	397	0.050	0.035	0.002	0.047	0.054

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Narcolepsy)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.1640	ns	1.000	ns
IBS	WEST	107	168	0.5240	ns	1.000	ns
IBS	SOUTH	107	83	0.0816	ns	0.816	ns
IBS	EAST	107	146	0.1660	ns	1.000	ns
WEST	SOUTH	168	83	0.1890	ns	1.000	ns
WEST	EAST	168	146	0.3880	ns	1.000	ns
SOUTH	EAST	83	146	0.5680	ns	1.000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Narcolepsy)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−1.330	0.184	.	white	−0.200	0.841	.	white	−1.330	0.184	.	white	−0.600	0.549	.	white
pct75.95	−2.140	0.032	*		−1.290	0.197	.	white	−2.140	0.032	*		−2.480	0.013	*
pct50.75	1.140	0.254	.	white	0.230	0.818	.	white	1.140	0.254	.	white	0.360	0.719	.	white
pct25.50	1.600	0.110	.	white	2.280	0.023	*		1.600	0.110	.	white	2.890	0.004	**
pct25	−0.030	0.976	.	white	−1.280	0.201	.	white	−0.030	0.976	.	white	−0.910	0.363	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference