Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Obesity_early_onset_extreme)
rsID	Risk allele	Effect size
rs1421085	C	0.365
rs476828	C	0.285
rs11208659	C	0.351
rs11109072	A	0.513
rs1048466	G	0.199
rs16923476	A	0.577
rs17025867	A	0.593
rs3782724	G	0.385
rs9328321	A	0.199
rs1631486	A	0.166
rs12408810	C	0.223
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Obesity_early_onset_extreme)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.068	0.022	0.002	0.064	0.071
SOUTH	83	0.068	0.022	0.002	0.064	0.073
EAST	146	0.072	0.023	0.002	0.069	0.076
Populations
IBS	107	0.071	0.021	0.002	0.067	0.075
PIR	397	0.069	0.022	0.001	0.067	0.072

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Obesity_early_onset_extreme)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.6200	ns	1.000	ns
IBS	WEST	107	168	0.2550	ns	1.000	ns
IBS	SOUTH	107	83	0.4690	ns	1.000	ns
IBS	EAST	107	146	0.5530	ns	1.000	ns
WEST	SOUTH	168	83	0.7940	ns	1.000	ns
WEST	EAST	168	146	0.0559	ns	0.559	ns
SOUTH	EAST	83	146	0.1870	ns	1.000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Obesity_early_onset_extreme)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	0.370	0.711	.	white	0.620	0.535	.	white	0.370	0.711	.	white	0.640	0.522	.	white
pct75.95	−0.220	0.826	.	white	−1.220	0.222	.	white	−0.220	0.826	.	white	1.010	0.312	.	white
pct50.75	−1.350	0.177	.	white	−1.110	0.267	.	white	−1.350	0.177	.	white	−2.160	0.031	*
pct25.50	−0.620	0.535	.	white	0.130	0.897	.	white	−0.620	0.535	.	white	0.190	0.849	.	white
pct25	2.030	0.042	*		1.770	0.077	.	white	2.030	0.042	*		0.700	0.484	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference