Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Osteoarthritis)
rsID	Risk allele	Effect size
rs80057746	T	0.195
rs7810100	T	0.082
rs12028630	G	0.074
rs1205424	G	0.064
rs116784579	C	0.142
rs1107427	G	0.085
rs231331	A	0.076
rs72740597	A	0.111
rs4498002	G	0.067
rs7510312	A	0.067
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Osteoarthritis)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.040	0.006	0.001	0.039	0.041
SOUTH	83	0.039	0.008	0.001	0.038	0.041
EAST	146	0.039	0.007	0.001	0.038	0.040
Populations
IBS	107	0.039	0.007	0.001	0.038	0.041
PIR	397	0.040	0.007	0.000	0.039	0.040

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Osteoarthritis)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.537	ns	1	ns
IBS	WEST	107	168	0.226	ns	1	ns
IBS	SOUTH	107	83	0.845	ns	1	ns
IBS	EAST	107	146	0.963	ns	1	ns
WEST	SOUTH	168	83	0.367	ns	1	ns
WEST	EAST	168	146	0.169	ns	1	ns
SOUTH	EAST	83	146	0.803	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Osteoarthritis)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	0.410	0.682	.	white	0.030	0.976	.	white	0.410	0.682	.	white	−0.220	0.826	.	white
pct75.95	−0.060	0.952	.	white	0.240	0.810	.	white	−0.060	0.952	.	white	0.180	0.857	.	white
pct50.75	0.230	0.818	.	white	0.880	0.379	.	white	0.230	0.818	.	white	0.340	0.734	.	white
pct25.50	−0.910	0.363	.	white	0.220	0.826	.	white	−0.910	0.363	.	white	−0.270	0.787	.	white
pct25	0.490	0.624	.	white	−1.370	0.171	.	white	0.490	0.624	.	white	−0.110	0.912	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference