Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Ovarian_cancer)
rsID	Risk allele	Effect size
rs3814113	T	0.191
rs11782652	A	0.174
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Ovarian_cancer)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	103	0.145	0.034	0.003	0.138	0.152
SOUTH	45	0.139	0.032	0.005	0.129	0.148
EAST	57	0.139	0.036	0.005	0.129	0.148
Populations
IBS	53	0.147	0.033	0.005	0.138	0.156
PIR	205	0.142	0.034	0.002	0.137	0.147

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Ovarian_cancer)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	53	205	0.361	ns	1	ns
IBS	WEST	53	103	0.783	ns	1	ns
IBS	SOUTH	53	45	0.249	ns	1	ns
IBS	EAST	53	57	0.213	ns	1	ns
WEST	SOUTH	103	45	0.296	ns	1	ns
WEST	EAST	103	57	0.247	ns	1	ns
SOUTH	EAST	45	57	0.984	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Ovarian_cancer)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct75.95	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct50.75	−0.410	0.682	.	white	0.490	0.624	.	white	−0.410	0.682	.	white	−0.690	0.490	.	white
pct25.50	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct25	0.410	0.682	.	white	−0.490	0.624	.	white	0.410	0.682	.	white	0.690	0.490	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference