Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Pancreatitis)
rsID	Risk allele	Effect size
rs12688220	T	0.326
rs379742	A	0.185
rs11988997	T	0.307
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Pancreatitis)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.042	0.050	0.004	0.034	0.049
SOUTH	83	0.032	0.047	0.005	0.021	0.042
EAST	146	0.049	0.057	0.005	0.040	0.059
Populations
IBS	107	0.030	0.044	0.004	0.022	0.039
PIR	397	0.042	0.052	0.003	0.037	0.048

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Pancreatitis)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.02900	*	0.2900	ns
IBS	WEST	107	168	0.07300	ns	0.7300	ns
IBS	SOUTH	107	83	0.83000	ns	1.0000	ns
IBS	EAST	107	146	0.00335	**	0.0335	*
WEST	SOUTH	168	83	0.15600	ns	1.0000	ns
WEST	EAST	168	146	0.17900	ns	1.0000	ns
SOUTH	EAST	83	146	0.01280	*	0.1280	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Pancreatitis)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	1.660	0.097	.	white	1.740	0.082	.	white	1.660	0.097	.	white	2.280	0.023	*
pct75.95	−0.330	0.741	.	white	1.220	0.222	.	white	−0.330	0.741	.	white	1.140	0.254	.	white
pct50.75	−0.320	0.749	.	white	0.150	0.881	.	white	−0.320	0.749	.	white	0.160	0.873	.	white
pct25.50	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white	0.000	1.000	.	white
pct25	−0.030	0.976	.	white	−1.710	0.087	.	white	−0.030	0.976	.	white	−1.950	0.051	.
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference