Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Parkinson-s_disease)
rsID	Risk allele	Effect size
rs17649553	C	0.262
rs34311866	C	0.239
rs35749011	A	0.601
rs12637471	G	0.172
rs1474055	T	0.194
rs76904798	T	0.144
rs117896735	A	0.485
rs9275326	C	0.191
rs199347	A	0.104
rs14235	A	0.098
rs11060180	A	0.100
rs12456492	G	0.104
rs8118008	A	0.105
rs6812193	C	0.095
rs11158026	C	0.104
rs10797576	T	0.123
rs591323	G	0.086
rs3793947	G	0.074
rs62120679	T	0.093
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Parkinson-s_disease)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.060	0.009	0.001	0.058	0.061
SOUTH	83	0.061	0.010	0.001	0.059	0.063
EAST	146	0.061	0.009	0.001	0.059	0.062
Populations
IBS	107	0.060	0.008	0.001	0.059	0.062
PIR	397	0.060	0.010	0.000	0.060	0.061

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Parkinson-s_disease)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.704	ns	1	ns
IBS	WEST	107	168	0.872	ns	1	ns
IBS	SOUTH	107	83	0.417	ns	1	ns
IBS	EAST	107	146	0.595	ns	1	ns
WEST	SOUTH	168	83	0.301	ns	1	ns
WEST	EAST	168	146	0.439	ns	1	ns
SOUTH	EAST	83	146	0.710	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Parkinson-s_disease)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	1.820	0.069	.	white	1.620	0.105	.	white	1.820	0.069	.	white	1.460	0.144	.	white
pct75.95	0.030	0.976	.	white	−1.690	0.091	.	white	0.030	0.976	.	white	0.590	0.555	.	white
pct50.75	−0.570	0.569	.	white	0.390	0.697	.	white	−0.570	0.569	.	white	−0.490	0.624	.	white
pct25.50	−0.150	0.881	.	white	−0.780	0.435	.	white	−0.150	0.881	.	white	−1.980	0.048	*
pct25	−0.170	0.865	.	white	1.100	0.271	.	white	−0.170	0.865	.	white	1.190	0.234	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference