Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Polycystic_ovary_syndrome)
rsID	Risk allele	Effect size
rs13429458	A	0.399
rs13405728	A	0.344
rs2479106	G	0.293
rs10818854	A	0.412
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Polycystic_ovary_syndrome)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	103	0.190	0.033	0.003	0.183	0.196
SOUTH	45	0.191	0.035	0.005	0.181	0.202
EAST	57	0.191	0.028	0.004	0.184	0.199
Populations
IBS	53	0.192	0.040	0.005	0.181	0.203
PIR	205	0.191	0.032	0.002	0.186	0.195

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Polycystic_ovary_syndrome)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	53	205	0.842	ns	1	ns
IBS	WEST	53	103	0.762	ns	1	ns
IBS	SOUTH	53	45	0.973	ns	1	ns
IBS	EAST	53	57	0.948	ns	1	ns
WEST	SOUTH	103	45	0.804	ns	1	ns
WEST	EAST	103	57	0.815	ns	1	ns
SOUTH	EAST	45	57	0.978	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Polycystic_ovary_syndrome)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	0.210	0.834	.	white	0.040	0.968	.	white	0.210	0.834	.	white	−1.820	0.069	.	white
pct75.95	−0.930	0.352	.	white	−0.480	0.631	.	white	−0.930	0.352	.	white	−0.050	0.960	.	white
pct50.75	−0.140	0.889	.	white	−0.930	0.352	.	white	−0.140	0.889	.	white	0.550	0.582	.	white
pct25.50	0.390	0.697	.	white	1.400	0.162	.	white	0.390	0.697	.	white	0.320	0.749	.	white
pct25	−0.180	0.857	.	white	−0.550	0.582	.	white	−0.180	0.857	.	white	−0.230	0.818	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference