Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Primary_biliary_cholangitis)
rsID	Risk allele	Effect size
rs7774434	C	0.470
rs12531711	G	0.457
rs485499	T	0.322
rs12134279	T	0.293
rs8017161	A	0.199
rs12924729	G	0.255
rs860413	A	0.262
rs2293370	G	0.300
rs11117432	G	0.270
rs538147	G	0.207
rs968451	T	0.239
rs1800693	C	0.199
rs1372072	A	0.182
rs6974491	A	0.223
rs7208487	T	0.278
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Primary_biliary_cholangitis)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.133	0.021	0.002	0.130	0.137
SOUTH	83	0.132	0.020	0.002	0.128	0.136
EAST	146	0.132	0.023	0.002	0.128	0.136
Populations
IBS	107	0.134	0.022	0.002	0.130	0.138
PIR	397	0.133	0.021	0.001	0.131	0.135

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Primary_biliary_cholangitis)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.625	ns	1	ns
IBS	WEST	107	168	0.901	ns	1	ns
IBS	SOUTH	107	83	0.543	ns	1	ns
IBS	EAST	107	146	0.548	ns	1	ns
WEST	SOUTH	168	83	0.583	ns	1	ns
WEST	EAST	168	146	0.590	ns	1	ns
SOUTH	EAST	83	146	0.926	ns	1	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Primary_biliary_cholangitis)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−1.350	0.177	.	white	−0.580	0.562	.	white	−1.350	0.177	.	white	−2.350	0.019	*
pct75.95	−0.860	0.390	.	white	−0.560	0.575	.	white	−0.860	0.390	.	white	0.640	0.522	.	white
pct50.75	1.150	0.250	.	white	1.070	0.285	.	white	1.150	0.250	.	white	0.890	0.373	.	white
pct25.50	−0.560	0.575	.	white	−0.840	0.401	.	white	−0.560	0.575	.	white	−1.280	0.201	.	white
pct25	0.990	0.322	.	white	0.670	0.503	.	white	0.990	0.322	.	white	0.950	0.342	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference