Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Prostate_cancer)
rsID	Risk allele	Effect size
rs6983267	G	0.223
rs77541621	A	0.713
rs10086908	T	0.157
rs9364554	T	0.131
rs10486567	G	0.157
rs3731827	T	0.122
rs7679673	C	0.113
rs10875943	C	0.113
rs902774	A	0.157
rs339331	T	0.122
rs13252298	A	0.104
rs17599629	G	0.131
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Prostate_cancer)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	65	0.068	0.013	0.002	0.065	0.071
SOUTH	38	0.061	0.013	0.002	0.056	0.065
EAST	89	0.062	0.014	0.001	0.059	0.065
Populations
IBS	54	0.067	0.017	0.002	0.063	0.072
PIR	192	0.064	0.014	0.001	0.062	0.065

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Prostate_cancer)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	54	192	0.07940	ns	0.7940	ns
IBS	WEST	54	65	0.82500	ns	1.0000	ns
IBS	SOUTH	54	38	0.02420	*	0.2420	ns
IBS	EAST	54	89	0.01810	*	0.1810	ns
WEST	SOUTH	65	38	0.01130	*	0.1130	ns
WEST	EAST	65	89	0.00606	**	0.0606	ns
SOUTH	EAST	38	89	0.71900	ns	1.0000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Prostate_cancer)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−1.930	0.054	.		−0.640	0.522	.	white	−1.930	0.054	.		−1.140	0.254	.	white
pct75.95	−0.650	0.516	.	white	0.070	0.944	.	white	−0.650	0.516	.	white	−1.420	0.156	.	white
pct50.75	0.890	0.373	.	white	1.170	0.242	.	white	0.890	0.373	.	white	0.710	0.478	.	white
pct25.50	−1.040	0.298	.	white	0.170	0.865	.	white	−1.040	0.298	.	white	−0.400	0.689	.	white
pct25	1.750	0.080	.	white	−1.200	0.230	.	white	1.750	0.080	.	white	1.580	0.114	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference