Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Psoriasis)
rsID	Risk allele	Effect size
rs7709212	T	0.223
rs17728338	A	0.432
rs4921493	T	0.231
rs842625	G	0.182
rs4795067	G	0.182
rs12564022	T	0.157
rs34394770	T	0.104
rs8128234	T	0.157
rs3730682	G	0.148
rs11922372	C	0.131
rs7352944	T	0.174
rs11795343	T	0.140
rs9304742	T	0.157
rs417065	A	0.157
rs6056869	A	0.113
rs2847500	A	0.131
rs10814247	G	0.077
rs57996174	C	0.113
Effect size: LN(OR)

Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Psoriasis)
	count	mean	sd	se	lower.ci	upper.ci
Pyrenean regions
WEST	168	0.060	0.011	0.001	0.058	0.062
SOUTH	83	0.061	0.011	0.001	0.059	0.063
EAST	146	0.063	0.015	0.001	0.060	0.065
Populations
IBS	107	0.062	0.012	0.001	0.060	0.064
PIR	397	0.061	0.013	0.001	0.060	0.062

Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Psoriasis)
group1	group2	n1	n2	p	p.signif	p.adj	p.adj.signif
IBS	PIR	107	397	0.4390	ns	1.000	ns
IBS	WEST	107	168	0.1380	ns	1.000	ns
IBS	SOUTH	107	83	0.4900	ns	1.000	ns
IBS	EAST	107	146	0.7550	ns	1.000	ns
WEST	SOUTH	168	83	0.5380	ns	1.000	ns
WEST	EAST	168	146	0.0485	*	0.485	ns
SOUTH	EAST	83	146	0.3060	ns	1.000	ns
* p < .05, ** p < .01, *** p < .001

Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Psoriasis)
Percentile rank	PIR				WEST				SOUTH				EAST
	adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val		adj.std.val	p.value	sig.val
pct95	−1.360	0.174	.	white	−0.450	0.653	.	white	−1.360	0.174	.	white	1.470	0.142	.	white
pct75.95	0.460	0.646	.	white	−1.590	0.112	.	white	0.460	0.646	.	white	−0.500	0.617	.	white
pct50.75	−0.570	0.569	.	white	−0.040	0.968	.	white	−0.570	0.569	.	white	0.260	0.795	.	white
pct25.50	−0.610	0.542	.	white	−0.230	0.818	.	white	−0.610	0.542	.	white	−1.120	0.263	.	white
pct25	1.310	0.190	.	white	1.870	0.061	.	white	1.310	0.190	.	white	0.440	0.660	.	white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference