Table 1.- Variants (SNPs) included in the PRS calculation
(Disease/Trait: Rheumatoid_arthritis)
rsID Risk allele Effect size
rs13192471 C 0.678
rs2230926 G 0.270
Effect size: LN(OR)
Table 2.- PRS Score distribution among populations and regions
(Disease/Trait: Rheumatoid_arthritis)
count mean sd se lower.ci upper.ci
Pyrenean regions
WEST 168 0.057 0.080 0.006 0.045 0.069
SOUTH 83 0.050 0.079 0.009 0.033 0.068
EAST 146 0.058 0.085 0.007 0.045 0.072
Populations
IBS 107 0.063 0.091 0.009 0.046 0.081
PIR 397 0.056 0.081 0.004 0.048 0.064
Table 3.- Pairwise t-test for PRS score among populations and regions
(Disease/Trait: Rheumatoid_arthritis)
group1 group2 n1 n2 p p.signif p.adj p.adj.signif
IBS PIR 107 397 0.420 ns 1 ns
IBS WEST 107 168 0.527 ns 1 ns
IBS SOUTH 107 83 0.278 ns 1 ns
IBS EAST 107 146 0.644 ns 1 ns
WEST SOUTH 168 83 0.549 ns 1 ns
WEST EAST 168 146 0.864 ns 1 ns
SOUTH EAST 83 146 0.468 ns 1 ns
* p < .05, ** p < .01, *** p < .001
Table 4.- Chi-square test comparison of percentile counts on Pyrenean regions compared to Iberian peninsula population
(Disease/Trait: Rheumatoid_arthritis)
Percentile rank PIR WEST SOUTH EAST
adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val adj.std.val p.value sig.val
pct95 −0.520 0.603 . white −0.650 0.516 . white −0.520 0.603 . white 0.150 0.881 . white
pct75.95 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white
pct50.75 −0.740 0.459 . white 0.210 0.834 . white −0.740 0.459 . white 0.030 0.976 . white
pct25.50 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white 0.000 1.000 . white
pct25 0.920 0.358 . white 0.020 0.984 . white 0.920 0.358 . white −0.090 0.928 . white
adj.std.val: Adjusted standardized residuals value; p.value: P value; sig.val: statistical significance, * p < .05, ** p < .01, *** p < .001; red dash to bottom: lower counts than reference; green dash to up: upper counts than reference